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Tadalafil

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Tadalafil is a prescription medicine for adult men with erectile dysfunction. This page is for the 10mg and 20mg strengths used when required.

Description

Tadalafil is a prescription medicine for adult men with erectile dysfunction. This page is for the 10mg and 20mg strengths used when required.

How does tadalafil work?

Tadalafil is a PDE5 inhibitor. During sexual stimulation it helps blood vessels in the penis relax, making it easier for blood to flow into the penis. It does not create desire or an automatic erection.

How to take on-demand tadalafil

Take the prescribed tablet whole with water before anticipated sexual activity.

  • Take it at least 30 minutes before sex.
  • Do not take more than one dose in 24 hours.
  • It can be taken with or without food.
  • Avoid grapefruit juice and excessive alcohol.
  • Do not take daily tadalafil, Cialis Daily, sildenafil, Viagra or another erectile dysfunction medicine at the same time unless specifically instructed.

What does “up to 36 hours” mean?

Tadalafil may make it easier to get an erection during a period of up to 36 hours after a dose. It does not cause a continuous erection, and sexual stimulation is still required.

If treatment does not work as expected

Do not take another dose on the same day. Contact the clinical team so that timing, dose, interactions, medical causes and alternative treatment can be reviewed.

Storage and disposal

Keep the medicine in its original packaging and follow the instructions for the supplied product. Keep it away from children and return unwanted medicine to a pharmacy.

Additional information

Strengths

10mg, 20mg

Pack Sizes

4 tablets, 8 tablets, 16 tablets, 32 tablets, 64 tablets

Strength

Strength Patient-facing explanation
10mg Usual on-demand starting strength for many adults, subject to assessment.
20mg Higher on-demand strength that may be considered when 10mg has not provided an adequate response and it is clinically appropriate.

Safety Accordion

Do not take this medicine if

  • You use nitrate medicines for chest pain, nitric oxide donors, recreational poppers containing nitrites or riociguat.
  • A clinician has advised that sexual activity is unsafe for you because of a heart or circulation condition.
  • You have had a serious allergic reaction to the active ingredient or another ingredient in the supplied product.
  • You have certain serious heart, blood-pressure, liver or eye conditions, or a recent heart attack or stroke, unless a prescriber has confirmed treatment is appropriate.

Tell the prescriber before treatment

  • Heart or circulation disease, very high or low blood pressure, kidney or liver problems.
  • A previous prolonged erection, sickle cell disease, leukaemia, multiple myeloma or an anatomical condition affecting the penis.
  • Previous sudden vision loss, serious eye disease, hearing problems, stomach ulcer or bleeding disorder.
  • Any new chest pain, breathlessness, fainting, dizziness on exertion or unexplained change in exercise tolerance.

Medicine and substance interactions

  • Other erectile dysfunction medicines, including any other tadalafil-containing product.
  • Nitrates, nitric oxide donors, riociguat, alpha-blockers and medicines for blood pressure or pulmonary hypertension.
  • Some antibiotics, antifungals, HIV medicines, epilepsy medicines and other medicines that affect tadalafil levels.
  • Grapefruit juice, excessive alcohol and recreational drugs, including poppers.
  • The patient must provide a complete list of prescriptions, over-the-counter medicines, supplements and recreational substances.

Side Effects

Common side effects

  • Headache
  • Indigestion
  • Back pain, muscle aches or pain in the arms and legs.
  • Facial flushing.
  • Blocked or stuffy nose.
  • Dizziness or feeling light-headed.

Get urgent medical help

  • Call 999 for chest pain, severe breathing difficulty, collapse, seizure or signs of a serious allergic reaction.
  • Seek urgent medical care for an erection lasting four hours or longer, or sooner if it is painful.
  • Get urgent advice for sudden loss or marked reduction of vision or hearing.
  • Do not take a further dose while a serious reaction is being assessed. Tell the healthcare professional what you took and when.
  • Report suspected side effects through the MHRA Yellow Card scheme where appropriate.

Patient Leaflet

  • The generic tadalafil page must link to the leaflet for the actual manufacturer and strength supplied.
  • Do not hard-code one generic product’s appearance, excipients or storage instructions if the manufacturer may change.
  • Make the exact supplied leaflet available in the patient account and with the medicine.

Clinical source link: Electronic Medicines Compendium – tadalafil search

FAQs

How long does tadalafil take to work?

It can start to work from around 30 minutes, although timing varies.

Does tadalafil give me an erection for 36 hours?

No. It may help you respond to sexual stimulation during that period; it does not cause a continuous erection.

Can I take tadalafil with food?

Yes. It can normally be taken with or without food.

What is the difference between tadalafil and Cialis?

Cialis is the branded version of tadalafil. Generic tadalafil contains the same active ingredient, while manufacturer, appearance, inactive ingredients and price may differ.

Can I take another tablet if it does not work quickly?

No. Do not take more than one dose in 24 hours.